Adjuvants in allergen-specific immunotherapy: New research results fresh from the Blank lab!

In experimental HDM AIT, a 220-fold reduced allergen dose is equally effective in control of allergic inflammation when HDM allergoids instead of extracts are applied. Low-dose non-adjuvanted allergoid AIT is less effective in inducing a potentially protective IgG1 response. Combining low-dose allergoid AIT with the adjuvant MCT or the adjuvant system MCT+MPL promotes Th1-inducing mechanisms and...
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DFG fördert Grundlagen-Projekt zu Stromazellen am ZAUM

Die Deutsche Forschungsgemeinschaft unterstützt in den kommenden drei Jahren ein Projekt von Dr. Szente-Pasztoi von der Gruppe Mukosale Immunologie, welches sich mit der Charakterisierung und Funktion von intestinalen Stromazellen befasst. Diese gewebsständigen Zellen finden sich in allen Körperorganen und sind maßgeblich an der Ausbildung von Struktur und Form jedes Organes beteiligt. Neueste...
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DFG Graduierten Kolleg RG2668: Immun-master Schalter in Allergie und Autoimmunität

Die DFG hat ein Graduierten Kolleg zum Thema "Immun-master Schalter in Allergie und Autoimmunität" bewilligt, das durch Prof. Tilo Biedermann geleitet wird und an dem sich ZAUM ebenfalls beteiligt.
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New discovery of suppressive secretoglobin 1A1 in cells of the lower airways.

Anti-inflammatory mechanisms from immune cells are intensively investigated. Here Uli Zissler and colleagues describe that SCGB1A1, an epithelial anti-inflammatory mediator is playing a role in allergen specific immunotherapy.
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Spotlight on miRNA in allergy!

miRNA are increasingly recognised to play an important role in control of allergic inflammation. This review provides an overview and defines knowledge gaps that need to be filled.  
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New video on mechanisms of allergen specific immunotherapy: Exhaustion?

Is exhaustion another mechanism of allergen specific immunotherapy? Have a look for this video & open access paper: An exhausted phenotype of TH2 cells is primed by allergen...https://youtu.be/ktECcpaecqs OR youtu.be/sBHcZR8KdGQ via @YouTube  
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New ZAUM website for pollen flight measurements

ZAUM released a new website, where anybody interested in pollen can check the latest measurements. The website is connected to newly installed robotic pollen monitors that deliver new data every 3 hours. The website is interactive and the displayed data can be adjusted to the user needs. Most monitors are situated in Bavaria in the project ePIN (electronic pollen information network), but new...
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