This publication combines outcomes from a very large, population-based prospective cohort study of adults to evaluate associations of dietary salt intake with allergic asthma incidence with results obtained using a mouse allergy model aimed at investigating underlying mechanisms of the high salt diet-induced disease exacerbation. The epidemiological study discovers novel associations between high intake of dietary salt and asthma incidence in females but not in males. Mechanistic data in female mice identify the induction of specific inflammatory T cell profiles and reduction of regulatory T cells, both of key immunological interest. Furthermore, high salt consumption induces alterations of short chain fatty acids in serum and of gut and lung microbiome.
Overall, the current study shows novel mechanisms that are triggered by high salt diet in lung allergic inflammation. Furthermore, changes in gut microbiota could be used to identify individuals who might benefit from salt intake reduction for the prevention of asthma or during its therapy.
This publication combines outcomes from a very large, population-based prospective cohort study of adults to evaluate associations of dietary salt intake with allergic asthma incidence with results obtained using a mouse allergy model aimed at investigating underlying mechanisms of the high salt diet-induced disease exacerbation. The epidemiological study discovers novel associations between high intake of dietary salt and asthma incidence in females but not in males. Mechanistic data in female mice identify the induction of specific inflammatory T cell profiles and reduction of regulatory T cells, both of key immunological interest. Furthermore, high salt consumption induces alterations of short chain fatty acids in serum and of gut and lung microbiome.
Overall, the current study shows novel mechanisms that are triggered by high salt diet in lung allergic inflammation. Furthermore, changes in gut microbiota could be used to identify individuals who might benefit from salt intake reduction for the prevention of asthma or during its therapy.
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