Publications
2024
Kohler, A., A. L. Geiselhoringer, D. Kolland, L. Kreft, N. Wichmann, M. Hils, M. Pasztoi, E. Zurkowski, J. Vogt, T. Kubelbeck, T. Biedermann, I. Schmitz, W. Hansen, D. Kramer, M. M. Gaida, C. B. Schmidt-Weber, N. Hoevelmeyer, and C. Ohnmacht. Mucosal Immunol. 2024; Apr 23:S1933-0219(24)00039-4. doi: 10.1016/j.mucimm.2024.04.002.Online ahead of print.
CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV
Immler, R., K. Nussbaumer, A. Doerner, O. El Bounkari, S. Huber, J. Abisch, M. Napoli, S. Schmidt, A. Margraf, M. Pruenster, I. Rohwedder, B. Lange-Sperandio, M. A. Mall, R. de Jong, C. Ohnmacht, J. Bernhagen, D. Voehringer, J. D. Marth, D. Frommhold, and M. Sperandio. Proc Natl Acad Sci U S A 2024; 121: e2319057121
Comparative Metagenomic Analysis of Bacteriophages and Prophages in Gnotobiotic Mouse Models
Ishola, O. A., S. Kublik, A. C. Durai Raj, C. Ohnmacht, S. Schulz, B. U. Foesel, and M. Schloter. Microorganisms 2024; 12(2):255
IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4
Hils, M., N. Hoffard, C. Iuliano, L. Kreft, N. Chakrapani, K. Swiontek, K. Fischer, B. Eberlein, M. Koberle, J. Fischer, C. Hilger, C. Ohnmacht, S. Kaesler, F. Wolbing, and T. Biedermann. J Allergy Clin Immunol 2024; 153: 1050-1062 e1056
TGF-beta specifies T(FH) versus T(H)17 cell fates in murine CD4(+) T cells through c-Maf
Chang, Y., L. Bach, M. Hasiuk, L. Wen, T. Elmzzahi, C. Tsui, N. Gutierrez-Melo, T. Steffen, D. T. Utzschneider, T. Raj, P. J. Jost, S. Heink, J. Cheng, O. T. Burton, J. Zeitrag, D. Alterauge, F. Dahlstrom, J. C. Becker, M. Kastl, K. Symeonidis, M. van Uelft, M. Becker, S. Reschke, S. Krebs, H. Blum, Z. Abdullah, K. Paeschke, C. Ohnmacht, C. Neumann, A. Liston, F. Meissner, T. Korn, J. Hasenauer, V. Heissmeyer, M. Beyer, A. Kallies, L. T. Jeker, and D. Baumjohann. Sci Immunol 2024; 9: eadd4818
2023
The aryl hydrocarbon receptor regulates lipid mediator production in alveolar macrophages
Maier, A. M., K. Huth, F. Alessandrini, B. Schnautz, A. Arifovic, F. Riols, M. Haid, A. Koegler, K. Sameith, C. B. Schmidt-Weber, J. Esser-von-Bieren, and C. Ohnmacht. Front Immunol2023; 14: 1157373
2022
Diversity of T Helper and Regulatory T Cells and Their Contribution to the Pathogenesis of Allergic Diseases
Ohnmacht, C., and S. Eyerich. Handb Exp Pharmacol2022; 268: 265-296
Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma
Lechner, A., F. D. R. Henkel, F. Hartung, S. Bohnacker, F. Alessandrini, E. O. Gubernatorova, M. S. Drutskaya, C. Angioni, Y. Schreiber, P. Haimerl, Y. Ge, D. Thomas, A. M. Kabat, E. J. Pearce, C. Ohnmacht, S. A. Nedospasov, P. J. Murray, A. M. Chaker, C. B. Schmidt-Weber, and J. Esser-von Bieren. J Allergy Clin Immunol 2022; 149: 2078-2090
PLGA-PEG-PLGA hydrogel as depot matrix for allergen-specific immunotherapy
Sonja Heine, Antonio Aguilar-Pimentel, Dennis Russkamp, Francesca Alessandrini, Valerie Gailus-Durner, Helmut Fuchs, Markus Ollert, Reinhard Bredehorst, Caspar Ohnmacht, Ulrich M. Zissler, Martin Hrabě de Angelis, Carsten B. Schmidt-Weber, Simon Blank. Pharmaceutics 2022; 14(8):1527
Luisa Kreft, Aloys Schepers, Miriam Hils, Kyra Swiontek, Andrew Flatley, Robert Janowski, Mohammadali Khan Mirzaei, Michael Dittmar, Neera Chakrapani, Mahesh S. Desai, Stefanie Eyerich, Li Deng, Dierk Niessing, Konrad Fischer, Regina Feederle, Simon Blank, Carsten B. Schmidt-Weber, Christiane Hilger, Tilo Biedermann, Caspar Ohnmacht. Front Immunol 2022; 13:958952
Alessandrini F, de Jong R., Wimmer M, Maier AM, Fernandez I, Hils M, Buters J, Biedermann T., Zissler U, Hoffmann C, Esser-von-Bieren J, Schmidt-Weber CB and Ohnmacht C. Front Immunol 2022
Tissue niches formed by intestinal mesenchymal stromal cells in mucosal homeostasis and immunity.
Pasztoi M and Ohnmacht C. Int J Mol Sci 2022; 23(9): 5181
NF-kB in control of regulatory T cell development, identity and function.
Hoevelmeyer N, Schmidt-Supprian M and Ohnmacht C. J Mol Med 2022; Online ahead of print.
2021
Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism.
Zeitler L, Fiore A, Meyer C, Russier M, Zanella G, Suppmann S, Gagaro M, Sidhu SS, Seshagiri S, Ohnmacht C, Köcher T, Fallarino F, Linkermann A, Murray PJ. Elife. 2021 Mar 1;10:e64806.
Papaioannou NE, Salei N, Rambichler S, Ravi K, Popovic J, Küntzel V, Lehmann CHK, Fiancette R, Salvermoser J, Gajdasik DW, Mettler R, Messerer D, Carrelha J, Ohnmacht C, Haller D, Stumm R, Straub T, Jacobsen SEW, Schulz C, Withers DR, Schotta G, Dudziak D, Schraml BU. Nat Commun. 2021 Jan 19;12(1):464.
2020
Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies.
Kreft L, Hoffmann C, Ohnmacht C. Front Immunol. 2020 Aug 14;11:1853.
de Los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, da Costa CP, Chaker AM, Brüne B, Nüsing R, Jakobsson PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J. Sci Transl Med. 2020 Apr 22;12(540):eaay0605.
2019
Andreas N, Potthast M, Geiselhöringer AL, Garg G, de Jong R, Riewaldt J, Russkamp D, Riemann M, Girard JP, Blank S, Kretschmer K, Schmidt-Weber C, Korn T, Weih F, Ohnmacht C.
J Immunol. 2019 in press
Sie C, Perez LG, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, Huber S, Krug A, Korn T.
J Immunol. 2019 Sep 15;203(6):1417-1427.
Aire-expressing ILC3-like cells in the lymph node display potent APC features.
Yamano T, Dobeš J, Vobořil M, Steinert M, Brabec T, Ziętara N, Dobešová M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedláček R, Hanayama R, Kolář M, Klein L, Filipp D.
Journal of Experimental Medicine 2019 doi: 10.1084/jem.20181430
IL-4 receptor α blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma.
Russkamp D, Aguilar-Pimentel A, Alessandrini F, Gailus-Durner V, Fuchs H, Ohnmacht C, Chaker A, de Angelis MH, Ollert M, Schmidt-Weber CB, Blank S.
Allergy 2019 doi: 10.1111/all.13759
Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions.
Van der Vorst EPC, Mandl M, Müller M, Neideck C, Jansen Y, Hristov M, Gencer S, Peters LJF, Meiler S, Feld M, Geiselhöringer AL, de Jong RJ, Ohnmacht C, Noels H, Soehnlein O, Drechsler M, Weber C, Döring Y.
Arterioscler Thromb Vasc Biol. 2019 doi: 10.1161/ATVBAHA.119.312386. [Epub ahead of print]
Defining Dysbiosis in Inflammatory Bowel Disease.
de Jong, R. and C. Ohnmacht.
Immunity 2019, 50(1): 8-10
2018
Ogawa, C., Bankoti, R., Nguyen, T., Hassanzadeh-Kiabi, N., Nadeau, S., Porritt, R., Couse, M., Fan, X., Dhall, D., Eberl, G., Ohnmacht, C. and G. Martins. Blimp1 functions as a molecular switch to prevent production of inflammatroy cytokines and loss of suppressor activity in RORγt+Foxp3+ Treg cells.
Cell reports, in press
2017
Barthels, C.#, Ogrinc, A.#, Steyer V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P., Ohnmacht, C., Garzetti., D., Stecher, B. and Brocker, T. CD40-signaling abrogates induction of ROR?t+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.
Nature communications 2017, in press
2016
Kepert, I., Fonseca, J., Mu?ller, C., Milger, K., Hochwind, K., Kostric, M., Fedoseeva, M., Ohnmacht, C., Dehmel, S., Nathan, P., Bartel, S., Eickelberg, O., Schloter, M., Hartmann, A., Schmitt- Kopplin, P., Krauss-Etschmann, S. D-Tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease.
Journal of Allergy and Clinical Immunology, doi 10.1016/j.jaci.2016.09.003, in press
Fedoseeva, M. & Ohnmacht, C. Wie die Darmflora Allergien verhindern kann.
Dtsch. Aertzteblatt. 2016, DOI: 10.3238/PersPneumo.2016.06.17.06
Ohnmacht, C. Microbiota, regulatory T cell subsets and allergic disorders.
Allergo J Int. 2016; 25(5):114-123
Ohnmacht, C. Tolerance to The Intestinal Microbiota Mediated by ROR(γt)+ Cells.
Trends Immunol. 2016 Jul;37(7):477-86.
2015
Ohnmacht, C.#, Park, J.H.#, Cording, S., Wing, J.B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I.G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S. and G. Eberl. MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORgammat(+) T cells.
Science 349, 989-993.
Wimmer, M.#, Alessandrini, F.#, Gilles, S., Frank, U., Oeder, S., Hauser, M., Ring, J., Ferreira, F., Ernst, D., Winkler, JB., Schmitt-Kopplin, P., Ohnmacht, C., Behrendt, H., Schmidt-Weber, C., Traidl-Hoffmann, C.*, Gutermuth, J*. Pollen-derived nonallergenic substances enhance Th2-induced IgE production in B cells.
Allergy 70, 944-54
2014
Massot, B., Michel, M.L., Diem, S., Ohnmacht, C., Latour, S., Dy, M., Eberl, G., and Leite-de-Moraes, M.C. (2014). TLR-induced cytokines promote effective proinflammatory natural Th17 cell responses.
J Immunol 192, 5635-5642.
2012
Cherrier, M.#, Ohnmacht, C.#, Cording, S.#, and Eberl, G. (2012). Development and function of intestinal innate lymphoid cells.
Curr Opin Immunol 24, 277-283.
2011
Lochner, M., Ohnmacht, C., Presley, L., Bruhns, P., Si-Tahar, M., Sawa, S., and Eberl, G. (2011). Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.
J Exp Med 208, 125-134.
Ohnmacht, C.#, Marques, R.#, Presley, L.#, Sawa, S.#, Lochner, M.#, and Eberl, G. (2011). Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity.
Cell Microbiol 13, 653-659.
2010
Ohnmacht, C.#, Schwartz, C.#, Panzer, M., Schiedewitz, I., Naumann, R., and Voehringer, D. (2010). Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.
Immunity 33, 364-374.
Ohnmacht, C., and Voehringer, D. (2010). Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells.
J Immunol 184, 344-350.
2009
Ohnmacht, C., Pullner, A., King, S.B., Drexler, I., Meier, S., Brocker, T., and Voehringer, D. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity.
J Exp Med 206, 549-559.
Ohnmacht, C., and Voehringer, D. (2009). Basophil effector function and homeostasis during helminth infection.
Blood 113, 2816-2825.
2008
King, SB., Knorn, AM., Ohnmacht C. and D. Voehringer. Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6.
J Immunol 2008 180:754-63.
2007
Ohnmacht, C., Pullner, A., van Rooijen, N., and Voehringer, D. (2007). Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity.
J Immunol 179, 4766-4774.
# contributed equally as first author.
* contributed equally as last author.