Publications

Seiringer P, Eyerich S, Eyerich K, Dittlein D, Pilz AC, Scala E, Ring J, Behrendt H, Cavani A, Traidl-Hoffmann C.

Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions.

Cells. 2021 Jun 26;10(7):1606. doi: 10.3390/cells10071606.                                                     

 

Thomas J*, Wang R*, Batra R, Böhner A, Garzorz-Stark N, Eberlein B, Theis F, Biedermann T, Schmidt-Weber C, Zink A, Eyerich K*, Eyerich S*.

CD23 levels on B cells determine long-term therapeutic response in atopic eczema patients treated with selective IgE immune apheresis

J Invest Dermatol. 2021 Mar;141(3):681-685.e6. doi: 10.1016/j.jid.2020.05.122. Epub 2020 Sep 17           

Lauffer F*, Baghin V*, Standl M, Stark SP, Jargosch M, Wehrle J, Thomas J, Schmidt-Weber CB, Biedermann T, Eyerich S, Eyerich K, Garzorz-Stark N.

Predicting persistence of atopic dermatitis in children using clinical attributes and serum proteins

Allergy. 2020 Aug 13. doi: 10.1111/all.14557. PMID: 32794228                                               

 

Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B.

Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal

Nat Immunol. 2020 May;21(5):555-566. doi: 10.1038/s41590-020-0666-9. Epub 2020 Apr 23.

 

Lauffer F, Jargosch M, Baghin V, Krause L, Kempf W, Absmaier-Kijak M, Morelli M, Madonna S, Marsais F, Lepescheux L, Albanesi C, Müller NS, Theis FJ, Schmidt-Weber C, Eyerich S, Biedermann T, Vandeghinste N, Steidl S, Eyerich K.

IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema.

J Eur Acad Dermatol Venereol. 2020 Apr;34(4):800-809. doi: 10.1111/jdv.16126. Epub 2020 Jan 19.

 

Gaffal E, Eming R, Fabri M, Gebhardt C, Stary G, Eyerich S, Hölzel M, Kosnopfel C, Neubert E, Rauer D, Rodríguez E, Thiem A, von Meyenn L, Buhl T.

Exp Dermatol. 2019 Sep;28(9):1094-1099. doi: 10.1111/exd.13990.                                    

 

Thomas J, Küpper M, Batra R, Jargosch M, Atenhan A, Baghin V, Krause L, Lauffer F, Biedermann T, Theis FJ, Eyerich K, Eyerich S, Garzorz-Stark N.

Is the humoral immunity dispensable for psoriasis pathogenesis

J Eur Acad Dermatol Venereol. 2019 Jan;33(1):115-122. doi: 10.1111/jdv.15101.       

 

Lauffer F, Jargosch M, Krause L, Garzorz-Stark N, Franz R, Roenneberg S, Böhner A, Mueller NS, Theis FJ, Schmidt-Weber CB, Biedermann T, Eyerich S, Eyerich K.

Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis

J Invest Dermatol. 2018 Mar 8. pii: S0022-202X(18)30215-X. doi: 10.1016/j.jid.2018.02.034.

 

Thomas J, Küpper M, Batra R, Jargosch M, Atenhan A, Baghin V, Krause L, Lauffer F, Biedermann T, Theis FJ, Eyerich K, Eyerich S, Garzorz-Stark N

J Eur Acad Dermatol Venereol. 2018 Jun 1. doi: 10.1111/jdv.15101.                                    

 

Hiller J*, Hagl B*, Effner R, Puel A, Schaller M, Mascher B, Eyerich S, Eyerich K, Jansson AF, Ring J, Renner ED, Traidl-Hoffmann C

STAT1/STAT3 imbalance determines the clinical phenotype of chronic mucocutaneous candidiasis

J Invest Dermatol. 2018 Mar;138(3):711-714. doi: 10.1016/j.jid.2017.09.035                       

 

Garzorz-Stark N*, Lauffer L*, Krause L, Thomas T, Atenhan A, Franz R, Roenneberg S, Boehner A, Jargosch M, Batra R, Mueller NS, Haak S, Groß C, Groß O, Traidl-Hoffmann C, Theis F, Schmidt-Weber CB, Biedermann T, Eyerich S*, Eyerich K*

TLR7/8 agonists stimulate plasmacytoid dendritic cells to initiate a Th17-deviated acute contact dermatitis in humans

J Allergy Clin Immunol. 2018 Apr;141(4):1320-1333.e11. doi: 10.1016/j.jaci.2017.07.045 

 

Mattii M*, Lovászi M*, Garzorz N, Atenhan A, Quaranta M, Lauffer F, Konstantinow A, Küpper M,  Zouboulis CC, Kemeny L, Eyerich K, Schmidt-Weber CB, Törőcsik D*, Eyerich S*

Sebocytes contribute to skin inflammation by promoting the differentiation of Th17 cells

Br J Dermatol. 2018 Mar;178(3):722-730. doi: 10.1111/bjd.15879. Epub 2018 Jan 9.      

 

Lovászi M, Mattii M, Eyerich K, Gácsi A, Csányi E, Kovács D, Rühl R, Szegedi A,  Kemény L, Ståhle M, Zouboulis CC, Eyerich S, Törőcsik D

Sebum lipids contribute to macrophage polarization and activation

Br J Dermatol, 2017 Dec;177(6):1671-1682. doi: 10.1111/bjd.15754                                   

 

Effner R, Hiller J, Eyerich S, Traidl-Hoffmann C, Brockow K, Triggiani M, Behrendt H, Schmidt-Weber CB, Buters JT.

Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop

Sci Rep. 2017 Mar 9;7:44005. doi: 10.1038/srep44005

 

Fischer J, Eberlein B, Hilger C, Eyer F, Eyerich S, Ollert M, Biedermann T.

Alpha-gal is a possible target of IgE-mediated reactivity to antivenom

Allergy. 2017 May;72(5):764-771. doi: 10.1111/all.13073.                                                   

 

Krause L, Mourantchanian V, Brockow K, Schmidt-Weber CB, Theis FB, Knapp B, Eyerich S#

A computational model to predict severity of atopic eczema from 30 serum parameters

J Allergy Clin Immunol. 2016 May 13. pii: S0091-6749(16)30279-2. doi: 10.1016/j.jaci.2016.04.018.

                                                                                                        

Garzorz N*, Krause L*, Lauffer F, Atenhan A, Thomas J, Stark SP, Franz R, Weidinger S, Balato A, Mueller NS, Theis FJ, Ring J, Schmidt-Weber CB, Biedermann T, Eyerich S, Eyerich K

A novel molecular disease classifier for psoriasis and eczema

Exp Dermatol. 2016 May 19. doi: 10.1111/exd.13077                                                                 

 

Garzorz N, Thomas J, Eberlein B, Haferlach C, Ring J, Biedermann T, Schmidt-Weber C, Eyerich K, Seifert F, Eyerich S.

Newly acquired kiwi fruit allergy after bone marrow transplantation from a kiwi-allergic donor.

J Eur Acad Dermatol Venereol. 2016 Mar 16. doi: 10.1111/jdv.13617.                              

 

Garzorz N, Alsisi M, Todorova A, Atenhan A, Thomas J, Lauffer F, Ring J, Schmidt-Weber C, Biedermann T, Eyerich S, Eyerich K

Dissecting susceptibility from exogenous triggers: the model of alopecia areata and associated inflammatory skin diseases

J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2429-35. doi: 10.1111/jdv.13325. Epub 2015 Sep 28                                                                               

 

Avitabile S, Odorisio T, Madonna S, Eyerich S, Guerra L, Eyerich K, Zambruno G, Cavani A, Cianfarani F

Interleukin-22 promotes wound repair in diabetes by improving keratinocyte pro-healing functions

J Invest Dermatol. 2015 Jul 13. doi: 10.1038/jid.2015.278.                                                         

 

Eberlein B, Hann R, Eyerich S, Pennino D, Ring J, Schmidt-Weber CB, Buters J

Optimizing the basophil activation test: comparison of different basophil identification markers

Cytometry B Clin Cytom. 2014 Nov 17. doi: 10.1002/cyto.b.21203                                       

 

Quaranta M, Eyerich S, Nasorri F, Scarponi C, Mattii M, Garzorz N, Onken AT, Jaeger T, Grosber M, Pennino D, Mempel M, Schnopp C, Albanesi C, Cavani A, Schmidt-Weber CB, Ring J, Eyerich K

Allergic contact dermatitis in psoriasis patients: typical, delayed, and non-interacting

PLoS One. 2014 Jul 24;9(7):e101814. doi: 10.1371/journal.pone.0101814                            

 

Quaranta M*, Knapp B*, Pullabhatla V, Garzorz N, Mattii M, Pennino P, Andres C, Traidl-Hoffmann C, Cavani A, Theis FB, Ring J, Schmidt-Weber CB, Eyerich S*, Eyerich K*

Intra-individual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

Sci Transl Med. 2014 Jul 9;6(244):244ra90. doi: 10.1126/scitranslmed.3008946.              

 

Derycke L, Eyerich S, Van Crombruggen K, Pérez-Novo C, Holtappels G, Deruyck N, Gevaert P, Bachert C.

Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps

PLoS One. 2014 Jun 9;9(6):e97581. doi: 10.1371/journal.pone.0097581.                               

 

Kretschmer A, Möller G, Lee H, Laumen H, von Toerne C, Schramm K, Prokisch H, Eyerich S, Wahl S, Baurecht H, Franke A, Claussnitzer M, EyerichK, Teumer A, Milani L, Klopp N, Hauck SM, Illig T, Peters A, Waldenberger M, Adamski J, Reischl E, Weidinger S.

A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding

Allergy. 2014 May;69(5):632-42. doi: 10.1111/all.12394.                                                   

 

Pennino D, Bhavsar PK, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham SR, Cavani A, Eyerich K, Chung FK, Schmidt-Weber CB, Eyerich S

IL-22 suppresses IFN-g mediated lung inflammation in Asthma

J Allergy Clin Immunol. 2013 Feb;131(2):562-70. doi: 10.1016/j.jaci.2012.09.036.           

Fischer-Stabauer M, Boehner A, Eyerich S, Carbone T, Pennino D, Quaranta M, Onken AT, Jaeger T, Traidl-Hoffmann C, Schmidt-Weber CB, Cavani A, Ring J, Hein R, Eyerich K

Differential in situ expression of IL-17 in skin diseases

Eur J Dermatol. 2012 Dec 1;22(6):781-4.  doi: 10.1684/ejd.2012.1854                               

 

Eyerich S*, Onken AT*, Weidinger S, Franke A, Nasorri F, Pennino D, Grosber  M, Pfab F, Schmidt-Weber CB, Mempel M, Hein R, Ring J, Cavani A, Eyerich K

Mutual Antagonism of the T cell Subsets Causing Psoriasis and Atopic Eczema

N Engl J Med. 2011 Jul 21;365(3):231-8. doi: 10.1056/NEJMoa1104200.                            

 

Liu L, Okada S, Kong XF, Kreins AY, Cypowyj S, Abhyankar A, Toubiana J, Itan Y, Audry M, Nitschke P, Masson C, Toth B, Flatot J, Migaud M, Chrabieh M, Kochetkov T, Bolze A, Borghesi A, Toulon A, Hiller J, Eyerich S, Eyerich K, Gulácsy V, Chernyshova L, Chernyshov V, Bondarenko A, María Cortés Grimaldo R, Blancas-Galicia L, Madrigal Beas IM, Roesler J, Magdorf K, Engelhard D, Thumerelle C, Burgel PR, Hoernes M, Drexel B, Seger R, Kusuma T, Jansson AF, Sawalle-Belohradsky J, Belohradsky B, Jouanguy E, Bustamante J, Bué M, Karin N, Wildbaum G, Bodemer C, Lortholary O, Fischer A, Blanche S, Al-Muhsen S, Reichenbach J, Kobayashi M, Rosales FE, Lozano CT, Kilic SS, Oleastro M, Etzioni A, Traidl-Hoffmann C, Renner ED, Abel L, Picard C, Maródi L, Boisson-Dupuis S, Puel A, Casanova JL.

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.

J Exp Med. 2011 Aug 1;208(8):1635-48. doi: 10.1084/jem.20110958.                                  

 

 

 

Eyerich S# , Wagener J, Wenzel V, Scarponi C, Albanesi C, Schaller M, Behrendt H, Ring J, Schmidt-Weber CB, Cavani A, Mempel M, Traidl-Hoffmann C, Eyerich K

IL-22 and TNF-a represent a key cytokine combination for epidermal integrity during infection with Candida albicans

Eur J Immunol. 2011 Jul;41(7):1894-901. doi: 10.1002/eji.201041197.                         

 

Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A.

IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes

J Immunol doi: 10.4049/jimmunol.0901767.                            

 

Carbone T, Nasorri F, Pennino D, Eyerich K, Foerster S, Cifaldi L, Traidl-Hoffmann C, Behrendt H, Cavani A.

CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.

J Immunol.  doi: 10.1684/ejd.2010.1096.                                  

 

Eyerich K, Böckelmann R, Pommer AJ, Foerster S, Hofmeister H, Huss-Marp J, Cavani A, Behrendt H, Ring J, Gollnick H, Bonnekoh B, Traidl-Hoffmann C.

Comparative in situ topoproteome analysis reveals differences in patch test-induced eczema: cytotoxicity-dominated Nickel- versus pleiotrope pollen-reaction.

Exp Dermatol. 2010 Jun;19(6):511-7. doi: 10.1111/j.1600-0625.2009.00980                        

 

CASE REPORTS

Weins AB, Mourantchanian V, Eyerich S, Biedermann T, Brockow K.

Delayed bullous pressure urticaria: the puzzling role of eosinophils.

J Dtsch Dermatol Ges. 2018 Oct;16(10):1253-1255. doi: 10.1111/ddg.13644

 

Garzorz N, Papanagiotou V, Atenhan A, Andres C, Eyerich S, Eyerich K, Ring J, Brockow K.

Pyoderma gangrenosum, acne, psoriasis, arthritis and suppurative hidradenitis (PAPASH)-syndrome: a new entity within the spectrum of autoinflammatory syndromes?

J Eur Acad Dermatol Venereol. 2014 Jul 28. doi: 10.1111/jdv.12631.                                    

 

REVIEW ARTICLES

 

Baumann R, Untersmayr E, Zissler UM, Eyerich S, Adcock IM, Brockow K, Biedermann T, Ollert M, Chaker AM, Pfaar O, Garn H, Thwaites RS, Togias A, Kowalski ML, Hansel T, Jakwerth C, Schmidt-Weber CB.

Non-invasive and minimally-invasive techniques for the diagnosis and management of allergic diseases.

Allergy. 2021 Apr;76(4):1010-1023. doi: 10.1111/all.14645.                                                

 

Sokolowska M, Lukasik Z, Agache I, Akdis CA, Akdis D, Akdis M, Barcik W, Brough H, Eiwegger T, Eliaszewicz A, Eyerich S, Feleszko W, Gomez Casado C, Hoffmann-Sommergruber K, Janda J, Jiménez-Saiz R, Jutel M, Knol E, Kortekaas Krohn I, Kothari A, Makowska J, Moniuszko M, Morita H, O’Mahony L, Nadeau K, Ozdemir C, Pali-Schöll I, Palomares O, Papaleo F, Prunicki M, Schmidt-Weber CB, Sediva A, Schwarze J, Shamji MH, Tramper-Stranders G, van de Veen W, Untersmayr E

Immunology of COVID-19: mechanisms, clinical outcome, diagnostics and perspectives – a report of the 1 European Academy of Allergy and Clinical Immunology (EAACI)

Allergy. 2020 Jun 25. doi: 10.1111/all.14462

 

Riggioni C, Comberiati P, Giovannini M, Agache I, Akdis M, Alves-Correia M, Antó MJ, Arcolaci A, Azkur AK, Azkur D, Beken B, Boccabella C, Bousquet J, Breiteneder H, Carvalho D, De las Vecillas L, Diamant Z, Eguiluz-Gracia I, Eiwegger T, Eyerich S, Fokkens W, Gao Y, Hannachi F, Johnston SL, Jutel M, Karavelia A, Klimek L, Moya B, Nadeau K, O'Hehir R, O’Mahony, L, Pfaar O, Sanak M, Schwarze J, Sokolowska M, J. Torres MJ, van de Veen W, van Zelm MC, De Yun Wang DY, Zhang L, Jiménez-Saiz R, Akdis CA

A compendium answering over 150 questions on COVID-19 and SARS-CoV-2

Allergy. 2020 Jun 14:10.1111/all.14449. doi: 10.1111/all.14449.                                        

 

Schön MP, Berking C, Biedermann T, Buhl T, Erpenbeck L, Eyerich K, Eyerich S, Ghoreschi K, Goebeler M, Ludwig RJ, Schäkel K, Schilling B., Schlapbach C, Stary G, von Stebut E, Steinbrink K.

COVID-19 and immunological regulations – from basic and translational aspects to clinical implications

J Dtsch Dermatol Ges. 2020 Aug 6:10.1111/ddg.14169. doi: 10.1111/ddg.14169.            

 

Maurer M, Eyerich K, Eyerich S, Ferrer M, Gutermuth J, Hartmann K, Jakob T, Kapp A, Kolkhir P, Larenas-Linnemann D, Park HS, Pejler G, Sánchez-Borges M, Schäkel K, Simon D, Simon HU, Weller K, Zuberbier T, Metz M.

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

Int Arch Allergy Immunol. 2020;181(5):321-333. doi: 10.1159/000507218. Epub 2020 Mar 30.

 

Venter C, Eyerich S, Sarin T, Klatt KC.

Nutrition and the Immune System: A Complicated Tango.

Nutrients. 2020 Mar 19;12(3):818. doi: 10.3390/nu12030818

Eyerich S, Metz M, Bossios A, Eyerich K

New biological treatments for asthma and skin allergies

Allergy. 2020 Mar;75(3):546-560. doi: 10.1111/all.14027. Epub 2019 Oct 8.                        

 

Eyerich S, Eyerich K, Traidl-Hoffmann C, Biedermann T.

Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network

Trends Immunol. 2018 Apr;39(4):315-327. doi: 10.1016/j.it.2018.02.004. Epub 2018 Mar 15.

 

Eyerich K, Eyerich S.

Immune response patterns in non-communicable inflammatory skin diseases

J Eur Acad Dermatol Venereol. 2017 Nov 8. doi: 10.1111/jdv.14673

 

Eyerich K, Eyerich S, Biedermann T.

The Multi-Modal Immune Pathogenesis of Atopic Eczema

Trends Immunol. 2015 Dec;36(12):788-801. doi: 10.1016/j.it.2015.10.006.                         

 

Eyerich S, Eyerich K

Th22 cells in allergic disease

Allergo J Int 2015;24:1–7                                                                                                                                

 

Eyerich S#, Zielinski C

Defining Th-cell subsets in a classical and tissue-specific manner: Examples from the skin

Eur J Immunol 2014, Dec;44(12):3475-83. doi: 10.1016/j.it.2010.06.004.                           

 

Eyerich S#, Eyerich K, Cavani A, Schmidt-Weber CB

Interleukin-17 and IL-22: siblings, not twins

Trends in Immunology 2010 Sep;31(9):354-61. doi: 10.1016/j.it.2010.06.004.                     

 

Eyerich K, Eyerich S, Hiller J, Traidl-Hoffmann C.

Chronic mucocutaneous candidiasis from bench to bedside.

Eur J Dermatol. 2010 May-Jun;20(3):260-5. doi: 10.1684/ejd.2010.0910.                              

 

BOOK CHAPTERS

 

Ohnmacht C, Eyerich S.

Diversity of T Helper and Regulatory T Cells and Their Contribution to the Pathogenesis of Allergic Diseases.

Handb Exp Pharmacol. 2021 Jul 11. doi: 10.1007/164_2021_486.