Publications

2017

Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma
Antonio Aguilar-Pimentel*, Anke Graessel*, Francesca Alessandrini, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrab? de Angelis, Dennis Russkamp, Adam Chaker, Markus Ollert, Simon Blank*, Jan Gutermuth*, Carsten B. Schmidt-Weber*
PLOS ONE, in press (2017)


Allergen-specific immunotherapy of Hymenoptera venom allergy - also a matter of diagnosis
Maximilian Schiener, Anke Graessel, Markus Ollert, Carsten B. Schmidt-Weber, Simon Blank
Human Vaccines and Immunotherapeutics, 13(10), in press (2017)


Component-resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergy
Simon Blank*, Stefanie Etzold, Ulf Darsow, Maximilian Schiener, Bernadette Eberlein, Dennis Russkamp, Sara Wolf, Anke Graessel, Tilo Biedermann, Markus Ollert*, Carsten B. Schmidt-Weber*
Human Vaccines and Immunotherapeutics, 13(10), in press (2017)


Benefits and limitations of recombinant allergens in diagnostics of insect venom allergy.
Edzard Spillner, Simon Blank, Thilo Jakob
In: Molecular Allergy Diagnostics. ed. Thilo Jakob; Jörg Kleine-Tebbe. Springer Verlag (2017)


Application of recombinant antigen 5 allergens from 7 allergy-relevant Hymenoptera species in diagnostics.
Maximilian Schiener*, Bernadette Eberlein*, Carmen Moreno-Aguilar, Gunilla Pietsch, Pilar Serrano, Mareike McIntyre, Lea Schwarze, Dennis Russkamp, Tilo Biedermann, Edzard Spillner, Ulf Darsow, Markus Ollert*, Carsten B. Schmidt-Weber, Simon Blank* 
Allergy,72(1): 98-108 (2017)

 

2016

Komponenten-aufgelöste Diagnostik der Hymenopterengiftallergie.
Anke Graessel, Maximilian Schiener, Stefanie Etzold, Dennis Russkamp, Simon Blank
BioSpektrum 22(7):713-716 (2016)

EAACI Molecular Allergology Users’s Guide.
P. M. Matricardi, J. Kleine-Tebbe, H. J. Hoffmann, R. Valenta, C. Hilger, S. Hofmaier, R.C. Aalberse, I. Agache, R. Asero, B. Ballmer-Weber, D. Barber, K. Beyer, T. Biedermann, M. Bilo, S. Blank, B. Bohle, P. P. Bosshard, H. Breiteneder,H. A. Brough, L. Caraballo, J. Caubet, R. Crameri, J. M. Davies, N. Douladiris, M. Ebisawa, P. A. Eigenmann, M. Fernandez-Rivas, F. Ferreira, G. Gadermaier, M. Glatz, R. G. Hamilton, T. Hawranek, P. Hellings, K. Hoffmann-Sommergruber, T. Jakob, U. Jappe, M. Jutel, S. D. Kamath, E.F. Knol, P. Korosec, A. Kuehn, G. Lack, A. L. Lopata, M. Mäkelä, M. Morisset, V. Niederberger, A. H. Nowak-Wezgrzyn, N. G. Papadopoulos, E. A. Pastorello, G. Pauli, T. Platts-Mills, L. K. Poulsen, M. Raulf, J. Sastre, E. Scala, J. M. Schmid, P. Schmid-Grendelmeier, M. van Hage, R. van Ree, S. Vieths, R. Weber, M. Wickman, A. Muraro, M. Ollert
Pediatric Allergy and Immunology, 27 (Suppl. 1): 1-236 (2016)

Allergien durch Stiche und Bisse von Insekten und Spinnentieren.
Simon Blank, Maximilian Schiener, Markus Ollert
Allergologie, 39(6): 265-273 (2016)

Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis.
Jana Michel, Knut Brockow, Ulf Darsow, Johannes Ring, Carsten Schmidt-Weber, Thomas Grunwald, Simon Blank*, Markus Ollert*
Allergy, 71(5): 651-660 (2016)

 

2015

Mehrwert und Grenzen rekombinanter Allergene in der Diagnostik der Insektengiftallergie.
Edzard Spillner, Simon Blank, Thilo Jakob
In: Molekulare Allergologie. ed. / Thilo Jakob; Jörg Kleine-Tebbe. Springer Verlag (2015)

Anaphylaxis to insect venom allergens: Role of molecular diagnostics.
Markus Ollert and Simon Blank
Current Allergy and Asthma Reports, 15:26 (2015)

Decline of Ves v 5-specific blocking capacity in wasp venom-allergic patients after stopping allergen immunotherapy.
Christian Möbs, Jan Müller, Annika Rudzio, Julia Pickert, Simon Blank, Thilo Jakob, Edzard Spillner, Wolfgang Pfützner
Allergy, 70(6): 715-719 (2015)

IgE recognition of chimeric isoforms of the honeybee (Apis mellifera) venom allergen Api m 10 evaluated by protein array technology.
Matthias van Vaerenbergh, Lina de Smet, David Rafei-Shamsabadi, Simon Blank, Edzard Spillner, Didier Ebo, Bart Devreese, Thilo Jakob, Dirk C. de Graaf
Molecular Immunology, 63(2): 449-455 (2015)

 

2014

Basophil activation test using recombinant allergens: highly specific diagnostic method complementing routine tests in wasp venom allergy.
Lukas Balzer, Davide Pennino, Simon Blank, Henning Seismann, Ulf Darsow, Mathias Schnedler, Mareike McIntyre, Markus Ollert, Steven R. Durham, Edzard Spillner, Johannes Ring, and Liliana Cifuentes
PLOS ONE, 9(10):e108619(2014).

Reply to: Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations.
Liliana Cifuentes, Simon Blank, Davide Pennino, Jana Michel, Ulf Darsow, Johannes Ring, and Markus Ollert
Journal of Allergy and Clinical Immunology, 134(2): 494-495 (2014)

Hymenoptera Allergens: From Venom to “Venome”.
Edzard Spillner, Simon Blank, Thilo Jakob
Frontiers in Immunology, 5:77 (2014)

Component resolution reveals additional major allergens in patients with honeybee venom allergy.
Julian Köhler*, Simon Blank*, Sabine Müller, Frank Bantleon, Marcel Frick, Johannes Huss-Marp, Jonas Lidholm, Edzard Spillner, and Thilo Jakob
Journal of Allergy and Clinical Immunology, 133 (5): 1383-1389 (2014).

Identification of hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens.
Liliana Cifuentes, Sebastian Vosseler, Simon Blank, Henning Seismann, Thomas Grunwald, Ulf Darsow, Reinhard Bredehorst, Martin Mempel, Edzard Spillner, Johannes Ring, and
Markus Ollert
Journal of Allergy and Clinical Immunology, 133 (3): 909-910 (2014).

 

2013

Donor Assists Acceptor Binding and Catalysis of Human alpha1,6-Fucosyltransferase.
Miriam P. Kötzler, Simon Blank, Frank I. Bantleon, Martin Wienke, Edzard Spillner, and Bernd Meyer
ACS Chemical Biology, 8 (8): 1830-1840 (2013).

Vitellogenins are new high molecular weight components and allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris venom.
Simon Blank, Henning Seismann, Mareike McIntyre, Markus Ollert, Frank I. Bantleon, and Edzard Spillner
PLOS ONE, 8(4):e62009 (2013).

Polistes species venom is devoid of carbohydrate-based cross-reactivity and allows interference free diagnostics.
Simon Blank, Charles Neu, Daniel Hasche, Frank I. Bantleon, Thilo Jakob, and Edzard Spillner
Journal of Allergy and Clinical Immunology, 131 (4): 1239-1242 (2013).

Extending the honeybee venome with the antimicrobial peptide apidaecin and a protein resembling wasp antigen 5.
Matthias van Vaerenbergh, Dries Cardoen, Ellen Formesyn, Marleen Brunain, Gonzalez van Driessche, Simon Blank, Edzard Spillner, Peter Verleyen, Tom  Wenseleers, Liliane Schoofs, Bart Devreese, and Dirk de Graaf
Insect Molecular Biology, 22 (2): 199-210 (2013).

 

2012

An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE.
Julia Hecker, Andrea Diethers, Daniela Schulz, Amir Sabri, Melanie Plum, Yvonne Michel, Martin Mempel, Markus Ollert, Thilo Jakob, Simon Blank, Ingke Braren, and Edzard Spillner
Allergy, 67 (12): 1530-1537 (2012).

Donor substrate binding and enzymatic mechanism of human core alpha1,6-fucosyltransferase (FUT8).
Miriam P. Kötzler, Simon Blank, Frank I. Bantleon, Edzard Spillner, and Bernd Meyer
Biochim Biophys Acta, 1820 (12): 1915-1925 (2012).

Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy.
Edzard Spillner, Ingke Braren, Kerstin Greunke, Henning Seismann, Simon Blank, Dion du Plessis
Biologicals, 40 (5): 313-322 (2012).

The putative serine protease inhibitor allergen Api m 6 from A. mellifera venom: recombinant and structural evaluation.
Yvonne Michel, Mareike McIntyre, Helene Ginglinger, Markus Ollert, Liliana Cifuentes, Simon Blank*, and Edzard Spillner*
J Investig Allergol Clin Immunol, 22 (7): 476-484 (2012).

Perspectives, pitfalls and current status of molecular diagnosis in insect venom allergy.
Edzard Spillner, Simon Blank, and Thilo Jakob
Allergo Journal, 21 (4): 249-256 (2012).

Recombinant IgE antibody engineering to target EGFR.
Edzard Spillner, Melanie Plum, Simon Blank, Michaela Miehe, Josef Singer, and Ingke Braren
Cancer Immunology and Immunotherapy, 61 (9): 1565-1573 (2012).

Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy.
Thilo Jakob, Julian Köhler, Simon Blank, Ulrika Magnusson, Johannes Huss-Marp, Edzard Spillner, and Jonas Lidholm
Journal of Allergy and Clinical Immunology, 130 (7): 276-278 (2012).

The major royal jelly proteins 8 and 9 (Api m 11) are glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate based reactivity.
Simon Blank, Frank I. Bantleon, Mareike McIntyre, Markus Ollert, and Edzard Spillner
Clinical and Experimental Allergy, 42 (6): 976-985 (2012).

 

2011

Close-up of the alpha-Gal epitope as defined by a monoclonal chimeric IgE and human sera using saturation transfer difference.
Melanie Plum, Yvonne Michel, Kathatrina Wallach, Tim Raiber, Simon Blank, Frank Bantleon, Andrea Diethers, Kerstin Greunke, Ingke Braren and Thomas Hackl, Bernd Meyer, and Edzard Spillner
Journal of Biological Chemistry, 286 (50): 43103-43111 (2011).

Formation of the immunogenic a1,3-fucose epitope: Elucidation of substrate specificity and of enzyme mechanism of core fucosyltransferase A.
Miriam P. Kötzler*, Simon Blank*, Henning N. Behnken, Dirk Alpers, Frank I. Bantleon, Edzard Spillner, and Bernd Meyer
Insect Biochemistry and Molecular Biology, 42 (2): 116-125 (2011).

Rekombinante Insektengiftallergene: Ist das Bienen- oder doch das Wespengift schuld?
Thilo Jakob, Simon Blank, Edzard Spillner, and Markus Ollert
Der Deutsche Dermatologe, 59: 759-761 (2011).

Stress-resistant neural stem cells positively influence regional energy metabolism after spinal cord injury in mice.
Karsten Schwerdtfeger, Angelika E.M. Mautes, Christian Bernreuther, Yifang Cui, Jérôme Manville, Marcel Dihné, Simon Blank, and Melitta Schachner
Journal of Molecular Neuroscience, 46 (2): 401-409 (2011).

Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts.
Simon Blank, Henning Seismann, Yvonne Michel, Mareike McIntyre, Ingke Braren, Thomas Grunwald, Ulf Darsow, Johannes Ring, Reinhard Bredehorst Markus Ollert, and Edzard Spillner
Allergy, 66 (10): 1322-1329 (2011).

Generation and epitope analysis of human monoclonal antibody isotypes with specificity for the timothy grass major allergen Phl p 5a.
Julia Hecker, Andrea Diethers, Stefanie Etzold, Henning Seismann, Yvonne Michel, Melanie Plum, Reinhard Bredehorst, Simon Blank, Ingke Braren*, and Edzard Spillner*
Molecular Immunology, 48 (9-10):1236-1244 (2011).

Evaluation of different glycoforms of honeybee venom major allergen phospholipase A2 (Api m 1) produced in insect cells.
Simon Blank, Yvonne Michel, Henning Seismann, Melanie Plum, Kerstin Greunke Thomas Grunwald, Reinhard Bredehorst, Markus Ollert, Ingke Braren, and Edzard Spillner
Protein and Peptide Letters, 18 (4): 415-422 (2011).

Reply to: Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy.
Silke Hofmann, Nikolai Pfender, Steffi Weckesser, Simon Blank, Johannes Huss-Marp, Edzard Spillner, and Thilo Jakob
Journal of Allergy and Clinical Immunology, 128 (1): 248 (2011).

Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy.
Gunter J. Sturm, Wolfgang Hemmer, Thomas Hawranek, Roland Lang, Markus Ollert, Edzard Spillner Simon Blank, Danijela Bokanovic, and Werner Aberer
Journal of Allergy and Clinical Immunology, 128 (1): 247-248 (2011).

 

2010

Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity.
Henning Seismann, Simon Blank, Liliana Cifuentes, Ingke Braren, Reinhard Bredehorst, Thomas Grunwald, Markus Ollert, and Edzard Spillner
Clinical and Molecular Allergy, 8: 7 (2010)


Identification, recombinant expression and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3.
Simon Blank, Henning Seismann, Benjamin Bockisch, Ingke Braren, Liliana Cifuentes, Mareike McIntyre, Dana Rühl, Johannes Ring, Reinhard Bredehorst, Markus Ollert, Thomas Grunwald, and Edzard Spillner
Journal of Immunology, 184 (9): 5403-5413 (2010).


Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3 core fucosylation.
Henning Seismann*, Simon Blank*, Ingke Braren, Kerstin Greunke, Liliana Cifuentes, Thomas Grunwald, Reinhard Bredehorst, Markus Ollert, and Edzard Spillner
Molecular Immunology, 47(4): 799-808 (2010).

 

2009

Components and mechanisms in diagnosis and therapy of hymenoptera venom allergy.
Simon Blank -/- Betreuer: Reinhard Bredehorst
Dissertation, Hamburg (2009)

 

2008

Recombinant IgY for improvement of immunoglobulin-based analytical applications.
Kerstin Greunke, Ingke Braren, Iris Alpers, Simon Blank, Jan Sodenkamp, Reinhard Bredehorst, and Edzard Spillner
Clinical Biochemistry, 41:1237-1244 (2008).

 

2007

Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries.
Ingke Braren, Simon Blank, Henning Seismann, Susanne Deckers, Markus Ollert, Thomas Grunwald, and Edzard Spillner
Clinical Chemistry, 53(5): 837-844 (2007).

 

*equal contribution as first or senior author

Contact

PD Dr. rer. nat. Simon Blank

Zentrum Allergie und Umwelt (ZAUM)
Technische Universität und Helmholtz Zentrum München


Ingolstädter Landstr. 1
85764 Neuherberg

Phone: +49 89 3187-2625
E-mail: Simon.blanknoSp@m@helmholtz-muenchen.de