Cytochrome P450s – metabolic keys in immunity
Cytochrome P450 enzymes (CYPs) oxidize lipophilic molecules and are well examined in the liver and environmentally exposed tissues. Renate Effner (research group Environment, Prof. Dr. Jeroen T. Buters) now reported that CYP1 enzymes are cleaners of the aryl hydrocarbon receptor (AHR) in human immune cells, thereby limiting the effects of ligands. The findings, which were elaborated in co-operation with the Chair and Institute of Environmental Medicine, (UNIKAT) TUM/HMGU, show that a reduced CYP1 activity amplifies AHR pathway related immunological targets such as the stem cell factor receptor (c-Kit) and the cytokine IL-22. Thus, CYP enzymes act at the interface between chemical exposure and immunological processes.
Effner, R. et al. Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop. Sci.Rep.7, 44005; doi:10.1038/srep44005 (2017).