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New article on macrophage memory in allergic asthma published in JACI

Monocytes and macrophages are known to develop an “innate memory”, also called “trained immunity” in different types of infections or cardiovascular disease. The team around first author Dr. Antonie Lechner (AG Esser-von Bieren) now shows that monocyte-derived macrophages from allergic asthmatics display a persistent inflammatory imprint and increased responsiveness to house dust mite. The authors further identify the cytokine TNF alpha as a key mechanism driving this inflammatory macrophage memory in house dust mite allergic asthma in vivohttps://www.jacionline.org/article/S0091-6749(21)02741-X/fulltext?dgcid=raven_jbs_aip_email