In experimental HDM AIT, a 220-fold reduced allergen dose is equally effective in control of allergic inflammation when HDM allergoids instead of extracts are applied.
Low-dose non-adjuvanted allergoid AIT is less effective in inducing a potentially protective IgG1 response.
Combining low-dose allergoid AIT with the adjuvant MCT or the adjuvant system MCT+MPL promotes Th1-inducing mechanisms and robust B-cell activation.