New discovery of suppressive secretoglobin 1A1 in cells of the lower airways.

Anti-inflammatory mechanisms from immune cells are intensively investigated. Here Uli Zissler and colleagues describe that SCGB1A1, an epithelial anti-inflammatory mediator is playing a role in allergen specific immunotherapy.

While several systemic immunomodulatory effects of allergen-specific immunotherapy (AIT) have been discovered, local anti-inflammatory mechanisms in the respiratory tract are largely unknown. We sought to elucidate local and epithelial mechanisms underlying allergen-specific immunotherapy in a genome-wide approach. Allergen-specific immunotherapy induces a yet unknown local gene expression footprint in the lower airways that on one hand appears to be a result of multiple regulatory pathways and on the other hand reveals SCGB1A1 as novel anti-inflammatory mediator of long-term allergen-specific therapeutic intervention in the local environmen

Allergen-specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways.

Zissler UM, Jakwerth CA, Guerth F, Lewitan L, Rothkirch S, Davidovic M, Ulrich M, Oelsner M, Garn H, Schmidt-Weber CB, Chaker AM.Allergy. 2021 Feb 2. doi: 10.1111/all.14756. Online ahead of print.PMID: 33528894