New article on the regulation of immune tolerance published in the Journal of Immunology


Regulatory T cells constitute a major T cell population that is necessary to prevent unwanted immune reactivity to both self- and foreign antigens including allergens. In collaboration with colleagues from Jena, the research group lead by Caspar Ohnmacht (shared first authors: Maria Potthast and Anna-Lena Geiselhöringer) could now show that the NF-kB family member RelB in dendritic cells regulates this regulatory T cell pool both in a qualitative and quantitative manner. Noteworthy, mice lacking RelB in dendritic cells were almost completely protected from a murine form of multiple sclerosis at the cost of impaired oral tolerance. Disentangling the underlying molecular network might therefore provide novel strategies to treat autoimmune diseases and allergic disorders in the future.