Neuherberg, August 2016: Adults suffering from a house dust mite allergy, exhibit a cascade of inflammatory signals on the surface of their airways, which leads to airway remodeling. This process cannot be influenced by standard cortisone therapy. In an experimental model researchers around Dr. Julia Esser-von Bieren (research group Immunemodulation) have reported that Wnt5a, the enzymes transglutaminase 2 and phospholipase A2 as well as leukotrienes are involved in this process. These findings were published in the latest issue of the ‘Journal of Allergy and Clinical Immunology’.
Age dictates a steroid resistant cascade of Wnt5a, transglutaminase-2 and leukotrienes in inflamed airways. DOI:10.1016/j.jaci.2016.07.014, Original Publication
Source: Helmholtz Zentrum München
Response to House Dust Mites is Age-Dependent
Immunohistochemical staining (nasal polyp tissue): components of the leukotriene cascade (green: leukotriene C4 synthase, red: cysteinyl leukotriene receptor 1) are active in epithelial cells and infiltrating inflammatory cells (cell nuclei in blue).
Head
Prof. Dr. rer. nat. Carsten B. Schmidt-Weber
Chair for Molecular Allergology (Klinikum rechts der Isar)
Director of the Institute of Allergy research (IAF; Helmholtz Zentrum München)
Contact
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